منابع مشابه
Inborn errors of sterol biosynthesis.
The known disorders of cholesterol biosynthesis have expanded rapidly since the discovery that Smith-Lemli-Opitz syndrome is caused by a deficiency of 7-dehydrocholesterol. Each of the six now recognized sterol disorders-mevalonic aciduria, Smith-Lemli-Opitz syndrome, desmosterolosis, Conradi-Hünermann syndrome, CHILD syndrome, and Greenberg dysplasia-has added to our knowledge of the relations...
متن کاملArtificial substrates in squalene and sterol biosynthesis.
Trans-(l-aH2]3-methylpent-2-enyl pyrophosphate and [l14C]isopentenyl pyrophosphate were incubated with 10,000 X g supematants of rat liver homogenates. Analyses of the unsaponiiiable material extracted from the incubations by gas-liquid radiochromatography and mass spectrometry revealed the synthesis not only of [14C]squalene but also of [SH, 14C]1 -methylsqualene and of [?H, 14C]1, 24-dimethyl...
متن کاملSterol Biosynthesis and Metabolism in Marine Invertebrates
The present state of knowledge on the ability of marine invertebrate animals to synthesise and metabolise sterols is reviewed. While animals from some phyla have a limited ability to synthesise sterols .a other groups of invertebrates are apparently incapable of sterol synthesis. It appears likely that much of the sterol of invertebrates originates from algae either in the plankton or living as...
متن کاملStructural genomics of enzymes involved in sterol/isoprenoid biosynthesis.
X-ray structures of two enzymes in the sterol/isoprenoid biosynthesis pathway have been determined in a structural genomics pilot study. Mevalonate-5-diphosphate decarboxylase (MDD) is a single-domain alpha/beta protein that catalyzes the last of three sequential ATP-dependent reactions which convert mevalonate to isopentenyl diphosphate. Isopentenyl disphosphate isomerase (IDI) is an alpha/bet...
متن کاملSterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs
Sterols are constituents of the cellular membranes that are essential for their normal structure and function. In mammalian cells, cholesterol is the main sterol found in the various membranes. However, other sterols predominate in eukaryotic microorganisms such as fungi and protozoa. It is now well established that an important metabolic pathway in fungi and in members of the Trypanosomatidae ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1969
ISSN: 0306-3283
DOI: 10.1042/bj1130020p